Sereno received his doctorate in communication studies from the University of Washington. He specializes in communication theory, persuasion and interpersonal communication. He has published numerous articles on persuasion and interpersonal communiction. He also is the co-author and co-editor of four books. He has directed 33 Ph.D. dissertations. He teaches courses in communication theory, persuasion, and interpersonal communication. He has received numerous teaching awards. He is the Faculty Advisor for the major Communication undergraduate professional organization: Annenberg Students Communication Association (ASCA).