Nguyen's research interests lie in the field of Information Communication Technologies and Society, with a focus on technology for social change, digital humanities, social inequalities, and online discrimination. Her studies investigate the role new media and digital technologies, such as the Internet, mobile phones and social media, play in transnational migration processes, the empowerment of underserved communities, and various forms of socio-political changes. She is also interested in issues of power, with one research trajectory focusing on the intersection of gender/class/race and technology, algorithm bias, and role of human agency in technology appropriation.

Her work has been published in the Journal of Information Technologies & International Development and International Journal of Communication. She also presented at international academic conferences such as International Communication Association, Information and Communication Technologies and Development, and International Association for Media and Communication Research.